The France Under-21 international is suspended after racking up a fifth yellow card of the season in the goalless draw against Brighton on Tuesday.
But Saints are hopeful on-loan Richard Chaplow will be available to slot into Schneiderlin's midfield role after he missed out in midweek with a slight Achilles problem.
Defender Dan Seaborne has resumed training following a thigh problem and could be added to the squad.
Manager Nigel Adkins may tinker with his line-up against the League Two side so Guly do Prado, David Connolly, Lee Holmes, Oscar Gobern and Aaron Martin could be in line for run-outs.
Source: PA
Source: PA