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Mondays scan on his calf strain proved inconclusive making him very doubtful for the fourth round tie with the Lions and also for next Tuesday's league trip to Sunderland.
Saints physio Jim Joyce said: "We are waiting for the results of the second scan before making a full assessment so we should have a clearer idea of the damage by Thursday."
The England full-back's 113 consecutive appearances is a current record for an outfield player.