Back-up goalkeeper Bartosz Bialkowski and French midfielder Morgan Schneiderlin are both major doubts for the south-coast derby clash due to knee injuries.
Forward Guly Do Prado is also unlikely to feature as he continues to recover from a hamstring problem which has seen him miss the last three games.
Striker Jonathan Forte, midfielder Oscar Gobern and defender Frazer Richardson will all be hoping for recalls following substitute appearances in midweek, although all three could be left on the bench following the convincing 3-0 win over Yeovil.
A win would take Saints level on points with the second-placed Cherries with two games in hand.
Source: PA
Source: PA