Defenders Fonte, Seaborne and Ostemobor were all cup-tied at the weekend and will come back into contention.
Their availability will give manager Alan Pardew a selection dilemma at the back with centre-half Radhi Jaidi returning on Saturday after an eye injury and makeshift right-back Wayne Thomas scoring Saints' opening goal.
Midfielder Dean Hammond is set to miss out again with an Achilles injury and striker David Connolly remains a doubt with groin trouble.
Source: Team Talk
Source: Team Talk