This has been a summer of change on the south coast, with Saints' best-ever Premier League finish swiftly followed by the rapid disintegration of their squad.
After manager Mauricio Pochettino and his staff left for Tottenham, long-serving duo Rickie Lambert and Adam Lallana moved to Liverpool either side of 19-year-old Luke Shaw's exit to Manchester United.
Those departures brought in upwards of £60million and the coffers are to be boosted further by the imminent exits of two more players.
Croatia international Lovren has made no secret of his desire to leave St Mary's just a year after joining the club in an £8.5million deal from Lyon.
The outspoken 25-year-old is now set to become the most expensive defender in Liverpool's history in a deal Press Association Sport understands to be worth £20million.
Lovren's exit has long been expected but Chambers' exit has come somewhat out of left field.
The 19-year-old impressed at right-back for Saints last season and it is understood Arsenal are willing to pay £16million to bring him to the Emirates Stadium.
Chambers, a graduate of the club's impressive academy, is keen to move to north London and did not feature in Friday's 1-0 friendly win in Bournemouth, although manager Ronald Koeman confirmed his absence was due to illness.
The pair are likely to be followed out of the club in the coming weeks by disruptive club-record signing Dani Osvaldo, while Jose Fonte and Morgan Schneiderlin are attracting interest.
So far Saints have managed to bring in just two players this summer, with Dusan Tadic joining from FC Twente before Graziano Pelle arrived from Koeman's former club Feyenoord.
Source : PA
Source: PA